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Side effects of sedating a horse

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Unfortunately, this affects both normal healthy cells and cancerous cells, and chemotherapy is associated with many serious side effects.

However, because cytotoxic substances have the most effect on fast-growing cells, such as cancer cells, they are an effective treatment for halting the spread of cancerous cells while having less impact on healthy tissues in most cases.

Activation of this system is a necessary step in the complex chain of events that results in inflammation.

So far, so good, but it turns out that horses also need COX enzymes for normal kidney function, for secretion of the protective lining that shields the intestines from damage and for production of blood cells.

Successful chemotherapy aims to maximize the destruction of cancerous cells and tumors while minimizing toxicity to the horse and their normal tissues.

Chemotherapy may be used in conjunction with surgical removal of cancerous masses and/or radiation therapy for the treatment of cancerous growths.

Dowling stressed the importance of having a vet oversee any use of sedatives, and feels that if the injectable form is used, a vet should administer the drug.

‘If either class of drug is accidentally given in the carotid artery rather than the jugular vein, it’s a bad wreck,’ she said.

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Get advice from experts to help inform your decisions. These medications are often used in horses to deal with situations where the horse might become anxious or aggressive: trailering, using clippers, or having teeth floated, for example. Trish Dowling, of the Western College of Veterinary Medicine, explained that there are two main categories of drugs used for this purpose in horses: the alpha-2 adrenergic agonists, which are prescription medications that are given by injection (xylazine, detomidine, romefidine) and must be obtained from a veterinarian; and the phenothiazines (usually acepromazine), which can be given by injection or in granules added to feed and do not require a prescription.

Remember all drugs have negative side effects, and some may even seem to go against prescribed indications.

Written by: Teresa Pitman Hear from veterinarians and horse owners about the pros and cons of using sedatives.

Currently, detomidine is only licensed for use in horses.

α2-adrenergic agonists produce dose-dependent sedative and analgesic effects, mediatated by activation of α2 catecholamine receptors, thus inducing a negative feedback response, reducing production of excitatory neurotransmitters.